Survey on Modelling Methods Applicable to Gene Regulatory Network

Chanda Panse and Manali Kshirsagar

ABSTRACT

Gene Regulatory Network (GRN) plays an important role in knowing insight of cellular life cycle. It gives information about at which different environmental conditions genes of particular interest get over expressed or under expressed. Modelling of GRN is nothing but finding interactive relationships between genes. Interaction can be positive or negative. For inference of GRN, time series data provided by Microarray technology is used. Key factors to be considered while constructing GRN are scalability, robustness, reliability and maximum detection of true positive interactions between genes. This paper gives detailed technical review of existing methods applied for building of GRN along with scope for future work.

KEYWORDS

Gene Regulatory Network, Microarray, robustness, scalability, reliability

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