Docking Studies on HIV Integrase Inhibitors Based on Potential Ligand Binding Sites

Subhomoi Borkotoky

Abstract

HIV integrase is a 32 kDa protein produced from the C-terminal portion of the Pol gene product, and is an attractive target for new anti-HIV drugs. Integrase is an enzyme produced by a retrovirus (such as HIV) that enables its genetic material to be integrated into the DNA of the infected cell. Raltegravir and Elvitegravir are two important drugs against integrase.

Keywords

Integrase, Chemsketch, Virtual screening.

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